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8. Crestor

2010 US Sales: $3.8 billion
Company: AstraZeneca

Crestor is a cholesterol drug designed to help lower LDL (bad) cholesterol and raise HDL (good) cholesterol. It also slows the progressions of atherosclerosis, a condition that blocks arteries.

Crestor is one of the most profitable drugs in AstraZeneca’s portfolio.

The patent for Crestor expires in 2016, at which time generic competition will be fierce.

Photo: Astrazeneca