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1. Biggby Coffee

Stores: 118
2010 Sales: $65 million

The first Biggby Coffee location opened in East Lansing, Mich., in March 1995. Since then, the chain's units have doubled every two years, according to the company. In 2010, Biggby grew from 110 locations to 118, a 7.3 percent increase, making it the fastest-growing coffee chain in the country.

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