The report identified 20 markets where a four-bedroom, two-bath house costs more than $1 million and eight markets where a similar home lists for less than $100,000. Thirteen of the country's 25 priciest markets are in California.
In contrast, 15 of the 25 cheapest markets are in the Midwest. New York casts the widest net, with markets ranked on both the most and least expensive lists.
(Read more: Credit cuts out would-be homebuyers)
While the U.S. has always been a wide-ranging real estate market, international investors are playing a bigger role—in high-end trophy properties as well as midrange homes.
"The U.S. is still the safest place to park capital," Huskey said. "Even in markets that historically you would not perceive to be those magnets—such as Manhattan or California or Florida. We looked at markets like San Antonio, Texas, and you'll find that 20 percent of the traffic on the website is coming from outside the United States."