Abbott Laboratories lost ground after reporting weaker-than-expected fourth-quarter revenue, hurt by disappointing sales of its generic drugs.
Brinker International rose after posting better-than-expected second-quarter earnings. Brinker is the owner of Chili's and Maggiano's restaurant chains.
Priceline.com, Google, Amazon.com and Facebook all hit record highs.
Intel moved lower after Drexel Hamilton downgraded the stock to hold from buy and cut its price target to $26 from $30 a share.
Medtronic came off its lows after the Supreme Court ruled in its favor in its dispute with privately owned Mirowski Family Ventures over whether it infringed on Mirowski's patents.
Dollar Tree fell after Sterne Agee downgraded the stock to neutral from buy and cut its price target to $56 from $63 a share.
Amag Pharmaceuticals lost ground after the FDA rejected its application for wider use of its iron deficiency drug due to safety concerns.
Salesforce.com fell despite being added to FBR Capital's top picks list.
UMB Financial rose after Sterne Agee upgraded the investment bank to buy and set a $675 a share price target.
(Read More: See CNBC's Market Insider Blog)
—By CNBC's Rich Fisherman.
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