"We got an email from Twitter and we crashed and broke Twitter. We have made history," DeGeneres said shortly after access to the social media site was disrupted due to sharing of her star-studded picture.
Kevin Spacey, Julia Roberts, Brad Pitt, Angelina Jolie and new Oscar winner Lupita Nyong'o, also crowded into the picture, which was snapped by Cooper after DeGeneres mingled with stars seated in the audience.
"I've never tweeted before!" Streep, a three-time Oscar winner, gushed after Cooper snapped the photo with a mobile device.
DeGeneres shared the selfie via her Twitter feed
It was shared, or retweeted, more than 2 million times in some two hours during the broadcast of the 86th annual Academy Awards.