Sony Network Entertainment International COO Shawn Layden will take Tretton's place on April 1.
Tretton was part of the team that launched the original PlayStation in 1995, and has worked at SCEA since then. He was promoted to lead the division in 2006.
"Working at SCEA for the past 19 years has been the most rewarding experience of my career," Tretton was quoted as saying in the press release. "Although I will deeply miss the talented team at SCEA and the passion demonstrated every day by our fans, I'm very excited about starting the next chapter of my career."
Details about what that next chapter will entail were not immediately available.