"It's opening a new medium, the virtual reality medium, for all sorts of opportunities in learning, in communication and in entertainment," Little said. "Advertising could be relevant, but also, if we're moving into the learning space, then the sales of course could be relevant."
Little said Facebook had the right credentials to monetize its new technology, given its track record on mobile. Despite relatively late adoption, Facebook now has 1 billion monthly active mobile users.
(Read more: Is Facebook's acquisition of WhatsApp a desperate move?)
Facebook's Frankfurt-listed stock traded 1.5 percent higher on Wednesday, following the announcement.
Analysts at RBC Capital Markets said it was too soon to predict any near-term financial implications for Facebook from the deal. However, they said it was unlikely the acquisition would change their current "outperform" rating on the stock.
Scott Redler, chief strategic officer at T3live.com, told CNBC that investors should look to buy Facebook's stock if it dipped to the $60 mark. "I think it's a very interesting stock," he said.