Investors remained cautious over geopolitical tensions in Ukraine and Russia.
Both the U.S. and the European Union expanded sanctions against Russia on Tuesday, targeting the country's energy, defense and financial sectors.
The sanctions are the toughest since the end of the Cold War, but Russia's benchmark MICEX Index still posted moderate gains on Wednesday, ending around 0.9 percent higher.
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Wall Street was mostly lower after second-quarter economic growth was reported at an annualized 4 percent, better than the 3 percent forecast. The strong number fueled concerns that the Federal Reserve might soon hike interest rates off record lows.
"The market can't ignore how this raises the stakes for the Fed. There are consequences to better growth, and that's a less accommodative Fed," said Peter Boockvar, chief market analyst at the Lindsey Group.
In the meantime, the Fed's latest monetary policy decision is due later on Wednesday. It is seen reducing monthly asset purchases by another $10 billion to $25 billion a month.