Prediction 2. The next generation of great entrepreneurs will be all about profits. Up to this point, investors and the press have been perhaps too easily dazzled by entrepreneurs who can show spectacular growth in revenues. There's some evidence that's beginning to change. For example, the fast-growing online storage company Box, led by Inc. Entrepreneur of the Year and NEXT LIST honoree Aaron Levie, withdrew its IPO earlier this year amid concerns that it was not yet in the black. Levie will be back, for sure, but the point has been made: Scale without profits will not make you great.
Read More7 superstar tweens and teens making a difference
Prediction 3. Some of the most successful of the NEXT LIST will turn out to be those who disrupted the First 25. For plenty of good reasons, the entrepreneurs on the CNBC NEXT LIST are founders who shook up legacy industries. For example, Shane Smith of Vice Media, Pete Cashmore of Mashable and Jonah Peretti of Buzzfeed all in their own way found success by redefining mainstream media. But remember, we're now talking 25 years from now. Over that time, industries that seem cutting edge in 2014 will have calcified and become ripe for disruption themselves. Facebook, for example, the great death star of social media, has already spawned a wave of revolutionaries like Wickr, ANSA and Omlet, aiming to make social media compatible with privacy.