To cater to this new wave of shoppers, the company—which has labeled 2015 "the year of the groom," announced a new partnership with Best Buy on Wednesday, and is talks with other male-centric retailers.
Read MoreMen may be to blame for those big credit card bills
"We were really surprised to see how many guests were adding tool sets from Home Depot or high-powered flashlights from Lowe's," said Nancy Lee, president of MyRegistry. "The kind of preconceived notion of what a gift registry is supposed to be is getting overshadowed little by little by reality."
MyRegistry.com users can drag and drop items from any retail website onto their universal registry. The site also syncs with the databases of 21 major retailers, including Macy's, Pottery Barn and Target. That way, shoppers can capitalize on the discounts and perks that these retailers offer newlyweds, while still being able to pool items from multiple stores.
Read MoreMenswear's moment as 'metrosexual' loses its stigma
Although MyRegistry's list of retailers has traditionally been made up of female-oriented or unisex companies (with the exception of outdoor brand REI), Lee said retailers that skew more toward male shoppers have begun approaching the site, after noticing the business MyRegistry was sending them.
"They're looking at us scratching their heads," Lee said.