He kept the same tone on Monday. Druckenmiller contended that waiting to raise rates "greatly increases the risk" for a negative reaction in the U.S. economy.
Read MoreEl Erian: Expect a Fed rate hike by September
He believes increased rates would slow the acceleration of corporate debt, saying that markets could withstand an increase of 25 to 50 basis points. Druckenmiller added that he was "very encouraged" by Fed Chair Janet Yellen's testimony before Congress last week.
"I thought she clearly is putting June on the table" for tightening monetary policy, he said.
Druckenmiller, who closed his hedge fund in 2010, touched on his investing picks and the ramifications of a "Grexit" in the interview, among other topics.
Read MoreEurope sees record inflows ahead of QE
Druckenmiller has "large exposure" in Japan and Europe, spurred on by monetary policy, he said. Europe's quantitative easing program has made the Continent's stocks particularly appealing, he added.
"The one thing we learned in the United States about QE is it definitely inflates financial asset prices. So the majority of my long exposure is in Japan and Europe and not in the United States," Druckenmiller said.
He added that uncertainty about a Greek exit from the euro zone, or Grexit, has already been priced into European markets.
The euro's slide against the dollar also bodes well for some European stocks, Druckenmiller said. The common currency has fallen nearly 20 percent against the dollar in the last year and traded around $1.12 on Monday.
Volkswagen, BMW and other "more cyclical" stocks could get a euro boost, Druckenmiller noted.
He also weighed in on Warren Buffett's confidence in IBM. The Dow laggard, in which Buffett held a roughly 8 percent stake as of Dec. 31, has shed 13 percent in the last year.
Druckenmiller believes IBM has a "secular problem" that it won't resolve soon.