It was not immediately clear how many of the 10 tornadoes reported to the National Weather Service — one in Missouri, one in Oklahoma, the rest in Kansas — would be confirmed by forecasters.
Elsewhere, a student at the University of Dayton in Ohio was seriously injured after he was struck by lightning. And four elementary students in Tulsa, Oklahoma, were hospitalized after their school bus rolled off Highway 75 in bad weather, the Tulsa World newspaper reported.
Despite the widespread damage, the first day of the predicted two-day event was not quite as severe as the onslaught feared by weather professionals.
"We were expecting a lot more," Weather Channel lead meteorologist Kevin Roth said. "Despite the damage, mainly caused by the wind and hail, you could say it didn't not quite live up to expectations, which is a good thing when it comes to severe weather."
Most of the first round of weather was done by midnight ET. Models were still shifting, but Roth said there could be a one-two punch effect on Thursday with two batches of severe weather hitting in the morning and then the afternoon.
Many of the same areas hit on Wednesday would likely be hit again, Roth said, with the worst of the storm possibly shifting east and north slightly toward the Ohio Valley and further into the Great Lakes.
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Chicago, St. Louis, and Cincinnati could all be under the storm's new danger zone, Roth said.
NBC News' Shamar Walters contributed to this report.