12 noon – NFL Draft rounds 4-7 (NFL Network/ESPN)
Now, this is the type of draft many people remember from years ago. It's an all-day marathon of picks, trades and optimism. In 1999, the Patriots drafted Tom Brady in the sixth round. He has since led New England to four Super Bowl victories.
6:30 p.m. – Kentucky Derby (NBC)
Better known as the Run for the Roses, this year's race has a guaranteed purse of $2 million. The early favorite is a horse named American Pharoah, while long-shot entries Ocho Ocho Ocho and Mr. Z were both listed with initial odds of 50-1.
8 p.m. – NBA: San Antonio Spurs vs. Los Angeles Clippers Game 7 (TNT)
9 p.m. – Mayweather vs. Pacquiao fight (Pay-per-view $99.95 for HD)
Some are calling this the fight of the century, and it certainly looks like a lock from a business perspective. Will the action in the ring live up to the hype?
11:30 p.m. – "Saturday Night Live" hosted by Scarlett Johansson (NBC)