Since December, more than 33.5 million turkeys and chickens have been destroyed or are scheduled to be destroyed, with 162 farms (and counting) confirmed hit by the virus across 16 states. Indiana and Nebraska both reported their first cases this week.
"Layer hens," which supply the country's eggs, have been hit hardest: More than 8 percent of the 300 million-plus U.S. layer hen population has disappeared in a month. (Tweet This)
The situation is particularly painful in Iowa, which is in the process of destroying more than 25 million chickens and turkeys. "We haven't seen anything like this, at least on the poultry side," said Bill Northey, secretary of Iowa's Department of Agriculture.
Read MoreInside Sunrise Farms' avian flu chicken slaughter
He noted that 1 in 3 layer hens in the state has come offline due to the flu—a worrisome stat for the country's top egg-producing state. Northey conceded that it's likely to result in lost business for local companies and lost revenue for Iowa's coffers.
With so much of the nation's supply abruptly yanked from the market, prices have started to soar. According to data from commodity analysis firm Urner Barry, the price of a dozen wholesale large Midwest shell eggs—the ones ultimately found at the store—has increased over the past three weeks by 36 percent, or 43 cents, to $1.62.
But the price of "breaker" eggs—the ones removed from their shells and used in other foods—is jumping even more dramatically: The price of a pound of liquid whole egg, an industry benchmark, is up 90 percent over the same period. Other types of processed egg products have already hit records, as prices double.
"Over half of all egg processors are in Iowa, so we're likely to see the ingredient market be even more greatly impacted than the shell market," Northey said.