Semiconductor equipment maker ASML was a top performer on the Stoxx 600. Shares finished up around 4.3 percent after the company reported second-quarter results and said sales this year would be higher than in 2014.
Luxury fashion brand Burberry reported a slowdown in first-quarter retail revenue, sending shares down 2.6 percent.
U.K. listed interdealer broker ICAP said revenue for the last quarter fell 1 percent compared to the same period in the year before on uncertainties over Greece. Despite this, shares remained in the green, closing up over 1.5 percent.
JD Wetherspoon said sales increased last quarter, but warned that the the U.K. government's plan for a higher "living wage" could create future uncertainty in the industry. Shares in the British pub group tanked, closing down around 8.4 percent.
Sweden's SKF, the world's biggest bearings maker, reported weaker-than-expected earnings on Wednesday sending shares 8.5 percent lower.
Meanwhile, software company Micro Focus ended down around 6.7 percent after investment firm Wizard sold shares in the group.