Spot gold fell more than 1.5 percent after the Fed announced that it would stay on course with its plan to trim its bond-buying program.
Bonds traded higher on Thursday after the US government's auction of 30-year Treasury bonds, the last of three debt auctions this week.
Asian shares were mixed on Wednesday due to caution over the Federal Reserve's policy meeting and the health of China's property market.
The euro fell against the dollar and pared its gains against the yen on Monday.
U.S. crude rose by more than $1, as strong gains in equities outweighed forecasts for another build in domestic supplies.
Gold futures settled 1 lower as global equities rose after Russian President Vladimir Putin's latest comments on Crimea lifted appetite for risk.
European shares closed lower on Friday after another volatile week dominated by events in Ukraine, with a referendum this weekend in Crimea.
Gold ended higher as investors added it as an insurance before a key vote in Crimea over the weekend to decide whether the region will join Russia.
U.S. bonds inched higher on Tuesday as concerns returned over the situation in Ukraine.
Gold settled lower after briefly touching a six-month high as appetite for risk remained cautious following Crimea's vote to break from Ukraine.
Stocks rallied on Monday as the voting in Crimea passed without violence and after U.S. manufacturing output jumped.
European stocks closed higher on Monday as the Crimea vote passed without violence and following positive U.S. data.
Crude oil fell sharply as concerns eased that fighting could erupt after Crimea voted to join Russia, and focus returned to fundamentals.
Asian stocks started the week mixed as concerns escalate over Ukraine after exit polls from a weekend referendum showed Crimea voting to join Russia.
Stocks declined on Friday as concern escalated about Ukraine.
U.S. stock index futures signaled a higher open to the week, as markets appeared to shrug off referendum ramifications in Crimea.
U.S. crude rose as traders watched Ukraine's crisis, but gains were curbed by domestic supply builds and lower demand in the U.S. and China.
Fears the crisis in Ukraine could intensify led traders to the safe havens of the Japanese yen and Swiss franc.
Asian shares traded mixed late Thursday. Domestic data lifted Australian stocks, while weaker-than-expected Chinese economic data limited gains in Shanghai.
The yen heads for its biggest weekly gain in more than a month against the dollar, on tensions in Ukraine and the Chinese economy.
Get the best of CNBC in your inbox