Gold fell to a three-week low, surrendering initial gains made after the European Central Bank cut interest rates to a record low.
Crude rose but remained within view of its lowest since early July, as Western powers stepped up efforts to reach a deal with Iran.
The euro fell to a more than seven-week low against the dollar after the European Central Bank shocked investors by cutting interest rates.
European equities closed lower on Tuesday after the European Union's Commission released a relatively subdued outlook for the economy.
U.S. stocks mostly climbed on Wednesday, with the Dow Jones Industrial Average closing at another record, as investors bought into optimism that the Federal Reserve would continue its stimulus.
Bond prices rose from technical support levels as investors waited for U.S. employment data and speeches by major Federal Reserve officials.
U.S. crude futures rebounded from four-month lows on unexpectedly large falls in U.S. fuel supplies.
Gold halted its longest losing streak in nearly six months, amid expectations the Fed will extend its monetary stimulus.
The euro rose as stronger-than-expected German industry data increased uncertainty over whether the ECB would cut interest rates this week.
Brent crude futures rose above $106 a barrel on Monday as tensions in major oil exporter Libya escalated.
Japan's benchmark index outperformed on Wednesday while the rest of Asian shaares were subdued as investors awaited direction from central banks.
U.S. stocks closed mainly down, with Wall Street pausing after a two-session rise.
Prices for U.S. Treasurys extended losses on Tuesday, after the U.S. service sector expanded more than expected in October.
U.S. crude oil futures hit a fresh 5-month low on Tuesday as stockpiles were expected to rise amid tepid demand.
Gold settled lower on Tuesday, pressured by a retreat in the euro ahead of a key European Central Bank meeting later this week.
The euro fell on Tuesday, hit by speculation the European Central Bank may signal easier monetary policy.
Asian stocks closed out Tuesday mixed in choppy trade as investors focused on central bank statements and awaited key U.S. economic data.
Stocks closed out Monday with slight gains after hovering around the flatline for most of the session, as investors seemed reluctant to jump in following a four-week rally and amid uncertainty over when the Federal Reserve would start paring back its stimulus.
European equities closed higher on Monday with expectations of monetary stimulus from the European Central Bank (ECB) driving shares.
Gold settled modestly higher lifted by a dollar drop and comments by a Fed official that the U.S. central bank should keep up its monetary stimulus.
Get the best of CNBC in your inbox