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Orexigen soars on drug data  Wed, 4 Mar '15 | 5:30 PM ET

Orexigan soared 11 percent in today's trade following the release of the drug-maker's positive data on its diet pill, Contrave, without FDA approval. Details, with CNBC's Meg Tirrell.

BAC's 'make or break' moment  Wed, 4 Mar '15 | 5:00 PM ET

With bank stress tests ahead, the Fast Money traders, discuss whether Bank of America will shock.

Euro: Look out below?  Wed, 4 Mar '15 | 5:15 PM ET

Marc Chandler, Brown Brothers Harriman, says the euro can head even lower on Thursday's European central bank meeting.

Midway's million dollar market  Wed, 4 Mar '15 | 4:44 PM ET

CNBC's Diana Olick goes inside three homes in one of the ten hottest housing markets in 2014: Chicago, Illinois. Dolly Lenz, CNBC contributor reveals which one comes with a million dollar price tag.

529s heat up CNBC.com  Wed, 4 Mar '15 | 4:53 PM ET

CNBC.com Managing Editor Allen Wastler reports college saving plans; the safety of Chinese products and retailers on the U.S. are the hottest topics on CNBC.com.

Robert Johnson, RLJ Companies founder, discusses the success of the show "Empire" and the reality of the public offering announced on the show.

How McDonald's makes its menu  Wed, 4 Mar '15 | 4:58 PM ET

Choosing which new burgers and fries make the cut is no small task for the world's fast food king. CNBC.com's Katie Little explains how McDonald's creates its menu.

Where to find the hottest new apps  Wed, 4 Mar '15 | 4:00 PM ET

Product Hunt, recently voted 'Best New Startup' at the Crunchies, is a website that highlights the 40 hottest new products and apps. Entrepreneurs whose products are highlighted can enjoy a lot of buzz and even venture capital investment. CNBC's Josh Lipton speaks with Ryan Hoover, Product Hunt's founder.

Sweet Briar closes down  Wed, 4 Mar '15 | 4:00 PM ET

Private women's college Sweet Briar says it will close down at the end of this year. A sign of more to come?

Key findings on the Fed's 2009 minutes  Wed, 4 Mar '15 | 4:00 PM ET

Jeff Cox and Steve Liesman break down minutes for 2009.

Obamacare on the line  Wed, 4 Mar '15 | 4:25 PM ET

CNBC's Dan Mangan and Deep Banerjee, S&P Health Care analyst, discuss the implications the Obamacare subsidies eligibility ruling will have on the health care industry.

Federal exchange subsidies fight  Wed, 4 Mar '15 | 4:22 PM ET

The latest challenge to Obamcare centers on the tax subsidies that make health insurance affordable for millions of Americans. Details, with CNBC's Hampton Pearson.

With nearly $200 billion under management, CalSTRS CIO Christopher Ailman, outlines current asset allocation and remains bias to the U.S.

Discussing factors impacting trade, with Jim LaCamp, UBS; Kenny Polcari, O'Neil Securities; FM trader Steve Grasso and CNBC's Sara Eisen.

CNBC's Jackie DeAngelis discusses the day's activity in the commodities markets. Oil was up on the day, in spite of a big build. Here's why

Godfather of ETFs: Bond market broken  Wed, 4 Mar '15 | 3:50 PM ET

Reggie Browne, Cantor Fitzgerald, sees flows into fixed income ETFs and those hedged to Europe.

Auto loans are up 29%. Discussing whether car buyers should pay cash or take the longer loan at a low interest rate, with Jonathan Clements, WSJ Finance columnist, and Mark Martiak, Premier Financial Advisors, who says it is a smart move to take advantage of low rates.

CNBC update: Lung cancer drug approved  Wed, 4 Mar '15 | 3:30 PM ET

Mexico arrests leader of Zetas drug cartel, Senate fails to override Obama's keystone veto and homeland security funding bill is signed, reports CNBC's Sue Herera.

Foundation to build portfolio: Pro  Wed, 4 Mar '15 | 3:25 PM ET

Beating the Street, Brian Peery, Hennessy Funds, explains what has driven the outperformance of the Hennessy Cornerstone Growth fund.

According to sources, HBO and Apple are in talks to partner on the streaming service HBO Now, reports CNBC's Julia Boorstin.

Ad-friendly Instagram  Wed, 4 Mar '15 | 3:40 PM ET

Demo of an Instagram feature that lets advertisers post multiple photos which users swipe through horizontally.

Utilities lose their power  Wed, 4 Mar '15 | 3:18 PM ET

Greg Gordon, ISI Group, makes the bear case against the utility sector. Mark Newton, Greywolf Execution Partners, thinks now is the time to buy into the space.

Fraud comes to apple pay  Wed, 4 Mar '15 | 2:46 PM ET

Michael Sansoterra, Silvant Capital Management, discusses how Apple can help banks verify and protect cardholders.

"Power Lunch" hosts Melissa Lee and Brian Sullivan look at 5 stocks with analyst recommendations, including T-Mobile US, Ambarella Inc, and CVR Refining.

Dissecting today's market action and the move in oil, with Keith Fitz-Gerald, Moneymorning.com; Jack Bouroudjian, Index Financial Partners; Monica Mehta, Seventh Capital; and CNBC's Rick Santelli.

The Senate failed to get the necessary 67 votes needed to override President Obama's Keystone XL pipeline veto, reports CNBC's Sue Herera.

Oil jumps into the close  Wed, 4 Mar '15 | 2:30 PM ET

CNBC's Jackie DeAngelis tracks oil's action into the close as crude inventory reaches record highs.

Esther George says central bank should raise interest rates in the middle of the year, FBI director James Comey is tracking down cybercrime, and Dr. Maya Angelou is honored, reports CNBC's Sue Herera.

CNBC's Morgan Brennan reports from Cushing, Oklahoma, the small town that doubles as the price settlement point for U.S. crude oil.

3 housing hot spots  Wed, 4 Mar '15 | 2:19 PM ET

With a combination of good job growth, easy comps, and inventory, David Goldberg, UBS analyst, explains which three locations are housing hot spots.

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