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  • Oil companies fight ND plan to slow production Tuesday, 22 Apr 2014 | 2:31 PM ET

    Lyle Best traveled nearly 200 miles from the heart of North Dakota's oil patch Tuesday to tell state regulators one thing: "Slow down."

  • AP Top Financial News At 2:10 p.m. EDT Tuesday, 22 Apr 2014 | 2:10 PM ET

    Valeant, Ackman make $45.6 B Allergan bid Novartis reshapes business with GSK, Lilly deals Earnings and corporate deals lift US stocks Job market for college grads better but still weak McDonald's 1 Q profit slips as US sales decline Comcast 1 Q earns surge on upbeat NBC results General Motors seeks more protection from suits GM restructuring engineering in response to recall E-cig industry awaits looming federal regulation Harley-Davidson 1 Q earnings roar ahead

  • AP Top Financial News At 1:29 p.m. EDT Tuesday, 22 Apr 2014 | 1:29 PM ET

    Novartis reshapes business with GSK, Lilly deals Valeant, Ackman make $45.6 B Allergan bid Earnings and corporate deals lift US stocks Job market for college grads better but still weak McDonald's 1 Q profit slips as US sales decline Comcast 1 Q earns surge on upbeat NBC results General Motors seeks more protection from suits GM restructuring engineering in response to recall E-cig industry awaits looming federal regulation Harley-Davidson 1 Q earnings roar ahead

  • The proposed Expedited Access Premarket Approval Application program would feature earlier and more frequent interactions between companies and FDA staff. The program is not a new pathway to market, the FDA said, but rather a change in approach aimed at reducing the time it takes to develop a product and get it to market.

  • AP Top Financial News At 12:46 p.m. EDT Tuesday, 22 Apr 2014 | 12:46 PM ET

    Novartis reshapes business with GSK, Lilly deals Valeant, Ackman make $45.6 B Allergan bid Stock gains continue amid earnings and deals Job market for college grads better but still weak McDonald's profit slips amid weak sales Comcast 1 Q earns surge on upbeat NBC results General Motors seeks more protection from suits GM restructuring engineering in response to recall E-cig industry awaits looming federal regulation Harley-Davidson 1 Q earnings roar ahead

  • LONDON, April 22- Barclays is to quit most of its commodities trading businesses, it said on Tuesday, joining a retreat prompted by falling profitability in the face of tougher regulation. Barclays said it would exit most of its metals, energy and agricultural trading but will continue trading precious metals, some oil and gas instruments and index products.

  • AP Top Financial News At 9 a.m. EDT Tuesday, 22 Apr 2014 | 8:57 AM ET

    McDonald's profit slips amid weak sales Comcast 1 Q earns surge on upbeat NBC results Valeant, Ackman make $45.6 B Allergan bid Novartis, GSK, Lilly in multibillion-dollar deals World stocks mixed on China worries, US earnings Harley-Davidson 1 Q earnings roar ahead E-cig industry awaits looming federal regulation Ahead of the Bell: US Existing Home Sales Travelers 1 Q results rise, increases dividend Japan, US struggle to bridge gap on freer trade

  • AP Top Financial News At 8:41 a.m. EDT Tuesday, 22 Apr 2014 | 8:41 AM ET

    McDonald's profit slips amid weak sales Comcast 1 Q earns surge on upbeat NBC results Novartis, GSK, Lilly in multibillion-dollar deals World stocks mixed on China worries, US earnings Valeant, Ackman make $45 B Allergan bid Harley-Davidson 1 Q earnings up 18.7 percent E-cig industry awaits looming federal regulation Ahead of the Bell: US Existing Home Sales Travelers 1 Q results rise, increases dividend Japan, US struggle to bridge gap on freer trade

  • AP Top Financial News At 7:03 a.m. EDT Tuesday, 22 Apr 2014 | 7:03 AM ET

    Comcast 1 Q earns beat Street on upbeat NBC result World stocks mixed on China worries, US earnings Novartis, GSK, Lilly in multibillion-dollar deals Botox maker Allergan draws bid from Valeant Ahead of the Bell: US Existing Home Sales Japan, US struggle to bridge gap on freer trade Powdered alcohols no longer have label approvals E-cig industry awaits looming federal regulation Netflix poised to raise prices after strong 1 Q German tax income jumps in 1st quarter

  • E-cig industry awaits looming federal regulation Tuesday, 22 Apr 2014 | 3:01 AM ET

    The Food and Drug Administration will propose rules for e-cigarettes as early as this month. Regulators aim to answer the burning question posed by Kenneth Warner, a professor at the University of Michigan School of Public Health: "Is this going to be the disruptive technology that finally takes us in the direction of getting rid of cigarettes?"

  • SHANGHAI, April 22- China's regulator posted draft initial public offering prospectuses for 18 Chinese firms on Monday, bringing the total number of potential issuers up to 46, with state media estimating they could raise as much as 22.6 billion yuan from investors.

  • *Plans to file for eteplirsen approval by end of 2014. April 21- Sarepta Therapeutics Inc's shares soared 64 percent after it said that the U.S. Food and Drug Administration indicated an alternate path to approval for the company's experimental muscle disorder drug.

  • Inside one Wall Street family's soap opera Monday, 21 Apr 2014 | 12:00 PM ET
    Karolina Albertson and Robert Albertson

    The wife of a chief strategist was arrested last month for alleged second-degree aggravated harassment of her husband's ex-wife, who is a top hedge fund exec.

  • Sarepta jumps on progress for muscle disorder drug Monday, 21 Apr 2014 | 11:32 AM ET

    NEW YORK— Shares of Sarepta Therapeutics surged Monday after the company said it plans to file for marketing approval of its muscle disorder drug eteplirsen by year-end. The Cambridge, Mass., company wanted to file for approval of eteplirsen in the first half of the year, but the Food and Drug Administration told Sarepta that that would be premature.

  • USDA establishes rural business investment program Monday, 21 Apr 2014 | 9:21 AM ET

    Secretary of Agriculture Tom Vilsack announced in Cedar Rapids the formation of the first Rural Business Investment Company, a for-profit firm licensed by the USDA to invest in businesses that otherwise might not have the capital to increase business opportunities. The USDA traditionally has offered guaranteed loans or direct loans for rural businesses.

  • The company hit a roadblock late last year when the health regulator said the design and goals of the previous trial may not be sufficient, citing new data on DMD and the failed trial of a competing drug made by Prosensa Holding NV.

  • Sarepta to start new trials on muscle disorder drug Monday, 21 Apr 2014 | 7:21 AM ET

    April 21- Sarepta Therapeutics Inc said it would start new trials to revive the chance of approval for its experimental muscle disorder drug after the U.S. Food and Drug Administration advised the company to submit new safety and efficacy data. Cambridge, Massachusetts- based Sarepta's stock jumped nearly 64 percent to $40 in trading before the bell on Monday.

  • Sarepta shares up 58%; FDA to review its drug Monday, 21 Apr 2014 | 6:55 AM ET
    Man with Duchenne muscular dystrophy controlling a motorized wheelchair with degenerated hands.

    Sarepta Therapeutics got the go-ahead to file for approval of its experimental drug for Duchenne muscular dystrophy.

  • BEIJING, April 21- China shares drifted lower on Monday, hit by concerns about a potential share oversupply after the securities regulator released draft prospectuses for 28 new companies planning to list. Shares in TBEA Co Ltd climbed 2.9 percent, while Henan Pinggao Electric Co Ltd gained 1.1 percent, and China XD Electric Co Ltd rose 1.3 percent.

  • As China Securities Regulatory Commission orders underwriters to update application materials once again, there have been no new China listing applications published for the past eight weeks.

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