The price action in DuPont, Cramer said, was nothing short of wild.
"Dupont, which had so disappointed last quarter, came out with a stellar 11-cent number, versus the 7-cents the Street was expecting. It looked like a major comeback."
Meanwhile, DuPont CEO, Ellen Kullman made some concerning comments on CNBC's Squawk Box.
"I think 2013, is setting up to be a cautious year, the question is how will the US economy respond," said Kullman.
The stock slipped in pre-market trading.
"However, within a few minutes I'm hearing that all anyone's really focused on is how the company's doing in agriculture, which turned out to be pretty darned good, especially in Latin America. And the latest DuPont earnings showed that margins have troughed with the commodity in question," Cramer said.
As a result, the stock – which had been sinking – reversed and started to fly again. Lesson: Shorting this stock would have hurt.
What's the bottom line?
"Believe me, if these were isolated examples, I would be fine with them. But they are par for the course and there are so many that are like these that you can see why I regard all of this trading off of headlines without knowing what people are really looking at to be just fraught with calamity and chances to lose money with almost every twist and turn," said Cramer
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