The storm centered its fury on Connecticut, Rhode Island and Massachusetts, with the highest snowfall total, 38 inches (97 cm), in Milford, Connecticut.
About 2,200 flights were canceled on Saturday, according to FlightAware, which tracks airline delays. Boston's Logan International Airport and Bradley International Airport in Windsor Locks, Connecticut, were shut down.
The storm dumped 29.3 inches (74 cm) of snow on Portland, Maine, breaking a 1979 record, the weather service said. Winds gusted to 83 miles per hour (134 km per hour) at Cuttyhunk, New York, and brought down trees across the region.
The storm contributed to three deaths in Connecticut, Governor Dannel Malloy told a news conference.
An 80-year-old woman was killed by a hit-and-run driver while clearing her driveway, and a 40-year-old man collapsed while shoveling snow. One man, 73, slipped outside his home and was found dead on Saturday, Malloy said.
A Boston fire official said an 11-year-old boy died from carbon monoxide poisoning. He was overcome by fumes as he sat in a running car to keep warm.
In Poughkeepsie, New York, a man in his 70s was struck and killed on a snowy roadway, local media reported.
A 30-year-old motorist in New Hampshire also died when his car went off the road, but the man's health might have been a factor in the accident, state authorities said.
Police in New York's Suffolk County, some using snowmobiles, rescued hundreds of motorists stuck overnight on the Long Island Expressway, said police spokesman Rich Glanzer.
Even as the big storm's force was slackening, the National Weather Service forecast a possible blizzard in the Great Plains.
Snow and, in some areas, blizzard conditions were expected across parts of Colorado, Nebraska, North Dakota, Minnesota, South Dakota and Wyoming through the weekend into Monday, it said.