The August job cuts were up 57 percent from the same time a year ago. For 2013 so far, employers have announced 347,095 job losses, close to the 352,185 that were seen in the first eight months of last year.
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Industrial goods manufacturers saw the biggest layoffs, cutting 22,162 employees, the largest total for the sector since January 2009.
"Heavy job cuts in the industrial goods sector are never a good thing, as they can be indicative of widening cracks in the economy's foundation," said John A. Challenger, chief executive officer of Challenger, Gray & Christmas.
"However, the August surge in industrial goods job cuts was driven largely by falling global demand for mining equipment," he said.
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The computer sector came in second, letting 4,663 workers go.
The figures come one day ahead of the key U.S. non-farm payrolls report, which is forecast to show the economy added 180,000 jobs in August, keeping the unemployment rate flat at 7.4 percent.