"It's the type of asset that's really not correlated with commodity prices, it's correlated with activity," del Ama said, calling energy infrastructure a type of "arbitrage to move oil from point A to point B."
The fund's offering is a reflection of one of the more curious byproducts of the U.S. oil boom. The world's largest economy pumps more oil than ever, but the largest oil companies are struggling to grab the benefits. Companies like ExxonMobil, Chevron, BP and Royal Dutch-Shell have been left in the dust by little-known companies—several of which comprise Global X's energy ETF.
(Read more: Exxon's trip from world's most valuable to dog of the Dow)
Judging by the numbers, the stocks in the Global X fund's components illustrate the dichotomy of Big Oil versus midstream companies. The smaller players have market capitalizations that are a fraction of their far larger counterparts.
Nonetheless, the numbers suggest a case of David beating Goliath, at least for now. Year-to-date, Access Midstream's stock has surged 55 percent, while EQT has jumped by a whopping 60.4 percent. Meanwhile, Exxon is virtually flat on the year, and has become one of the Dow Jones industrial average's worst-performing blue chips.
Global X's del Ama says the abundant U.S. natural gas and unconventional oil plays create "pretty significant pipelines to transport that energy around." As long as the boom continues, smaller players are in the best position to benefit, he added.
"To the extent that the energy renaissance we've experienced, if that continues, it certainly is a positive for the industry," del Ama said.
—By CNBC's Javier E. David.