President Barack Obama revealed earlier this week first lady Michelle Obama is "very wary and suspicious" of any military action against the government of Syrian leader Bashar Assad for using chemical weapons.
Now on the other side of the aisle, Sen. Bob Corker, R-Tenn., told CNBC on Wednesday he hears from his wife about the possibility of further U.S. involvement there.
In an address to the nation on Tuesday night, the president acknowledged the fatigue and concern felt by his wife and Elizabeth Corker and many other Americans about the U.S. getting involved in another conflict in the region.
(Read more: Obama will try more diplomacy on Syria)
"My wife, when I get home on the weekends wears me out, over the Middle East," Corker, ranking member of the Senate Foreign Relations Committee, said in a "Squawk Box" interview. "But I think there are larger issues here."
"When our commander-in-chief draws a bright red line and a country passes that, to me it's about our credibility as a nation," Corker said. "To me, it has more to do with Iran, and actions down the road, and our credibility and whether we can be counted upon."
Obama also said in his speech he remains ready to order U.S. missile strikes against Assad should Russia fail in its diplomatic efforts to get Syria to hand over its deadly chemical weapons stocks.
Corker said he has "zero trust of Russia" but hopes its diplomatic overtures will succeed. The diplomacy should be pursued for a "period of time," he said.
In a separate interview on "Squawk Box," Sen. Heidi Heitkamp, D-N.D., advocated giving diplomacy a chance.
"[But] we need that verified, not just talk," she said. "And we're going to have to take a look after that."
Heitkamp, member of the Homeland Security committee, co-authored a resolution last week to first seek a diplomatic approach to Syria by requiring Assad to sign the chemical weapons ban in 45 days; and if not, the Senate would give the president the authority to respond.