Since 2006, the agency has required food companies to include transfat content on nutritional labels. The fats are often found in cakes, cookies and pies; prepared icings; microwave popcorn; frozen pizza; margarine and other spreads; and refrigerator-dough products. A label listing partially hydrogenated oil indicates that transfat is present.
"Providing consumers with high-quality, great-tasting products is a priority for us," Mondelēz said in a statement. The company once faced a lawsuit before removing the transfat from its Nabisco-brand Oreo cookies. "In our U.S. product portfolio, all of our cookies and crackers are labeled as 'zero grams transfat' per serving."
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Several companies issued similar statements in response to the FDA plan.
"General Mills will be very responsive to this new request for comment from the FDA. Partially hydrogenated oil (PHO) has always been considered safe for use by FDA, and by the food industry as well. This is a major development. ... " the company said in a statement sent to CNBC.
"General Mills had already been working quickly to reduce the use of PHOs in products as the science began to shift on transfats—and more than 90 percent of our U.S. retail products are already labeled as zero grams transfat. But we will also need to move to respond quickly to FDA on this question, and we will."
Nestlé echoed that sentiment.
"We fully support the efforts of the FDA to improve public health," Nestlé spokeswoman Hannah Coan said in a statement. "The large majority of Nestlé foods and beverages do not contain partially hydrogenated oils (added transfats) as we have been actively working to remove them from our foods. We have made good progress and will continue our journey to remove all remaining partially hydrogenated oils."
Tyson Foods said it changed cooking oils in 2007 to remove transfats from breaded poultry products.
"This was done with an eye toward zero impact on taste or texture," Tyson spokeswoman Krista Cupp said in a statement to CNBC. "While Tyson chicken products are naturally low in transfat, it can be found in certain added ingredients such as cooking oils, which led to the reformulation of the company's breaded poultry portfolio."
Hormel also said it was close to the target.
"As many of our products are protein-based pork and turkey items, more than 97 percent of our branded retail portfolio does not contain partially hydrogenated oils. ... During the past few years we have been working with our suppliers to further eliminate PHOs from the few remaining products that contain them," Hormel said in a statement.
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Those efforts are the norm for the industry, according to a statement from the Grocery Manufacturers Association, which represents more than 300 businesses in the consumer packaged goods industry and related fields.
"Since 2005, food manufacturers have voluntarily lowered the amounts of transfats in their food products by over 73 percent," the group's statement said. "Consumers can be confident that their food is safe, and we look forward to working with the FDA to better understand their concerns and how our industry can better serve consumers."