Nikkei 0.4% lower
Japanese equities posted a second straight session of losses as dollar-yen continued to retreat from a six-month high hit earlier this week.
(Read more: Dollar-yen trade is back...and could be better than ever)
Some tech shares climbed following upbeat revenue results from Hewlett-Packard. Nikon and Canon rose 2.6 and 0.8 percent, respectively.
Online retailer Rakuten surged over 6 percent after being promoted to the Topix index.
Panasonic climbed 3.4 percent after sources reported the firm will sell three domestic semiconductor factories to an Israeli firm in an attempt to finalize the sale of loss-making businesses.
Sydney 0.4% lower
Australian miners weighed on the resource-heavy index on the back of lower commodity prices and after data on Wednesday showed declining investment in new resource projects.
Gold miners were the worst hit after bullion prices steadied after dropping nearly 1 percent overnight. Silverlake Resources slumped 14 percent while Kingsgate Consolidated fell 9 percent.
Home builders were declined despite data showing the value of national construction work in the third-quarter beat forecasts to rise 2.7 percent. Boral and Bluescope Steel lost over 1 percent each.
Kospi up 0.3%
South Korea's benchmark index erased early losses to end higher for the fourth straight day despite weak economic data. December's manufacturing outlook fell from a near two-year high in November, indicating that the recovery in Asia's fourth-largest economy remains fragile.
(Read more: These markets are struggling – Blame the yen)
Industrial Bank of Korea slumped over 4 percent on news that the government is selling 13.1 million shares in the state-owned lender.
— By CNBC.com's Nyshka Chandran. Follow her on Twitter