Jarvis said Home Depot has been working on an alternative to neonicotinoids for some time and that several of the retailer's suppliers are already using the replacements. He said that anti-pesticide petitioners who have been in the stores this week have been very polite—and that anytime someone has an issue with a Home Depot product, it is taken seriously.
Lowe's has not made any public statements or responded to meeting requests from Friends of the Earth, said Archer. (Calls to the company's corporate offices were not returned in time for this story.)
Another historic bee die-off
Bees and other pollinators are critical in producing—through the pollination of plants—two-thirds of the food crops humans eat every day. It's estimated that between $20 billion and $30 billion in American agriculture production depends on honeybees and other pollinators.
Read more: Pacific storm eases California drought, but state has long way to go)
But the bees are dying by the billions. The common name for what's killing them is Colony Collapse Disorder.
Last year, U.S. beekeepers reported losing 40 to 100 percent of their hives, and they are likely facing another winter of historic bee die-offs, according to the Friends of the Earth.
—By CNBC's Mark Koba. Follow him on Twitter