Inevitably, with a limit of 200 contenders across the board, some names didn't make the list. So who did CNBC leave out?
An overwhelming favorite is Tim Berners-Lee, who, with apologies to Al Gore, created the World Wide Web in 1989.
Brynjolfsson also likes Nicholas Negroponte, founder of the MIT Media Lab, which pioneered devices similar to Google Glass in the 1990s.
The list is pretty Western-heavy but Forrester's Frank Gillett said there's a lot of disruption going on abroad, too.
"It's interesting there aren't more Chinese innovators," Gillett said. He suggested Lenovo's founder Liu Chuanzhi and Sina's CEO Charles Chao, among others.
Based in the United Kingdom, analyst Devlin has a top pick that is probably a name you've never heard of: Olivier Piou, CEO and founding member of the Dutch company Gemalto. Established in 2006, the firm is a market leader in mobile phone SIM cards, mobile payments for banks, NFC (mobile communication by proximity) and digital transactions.
(Read more: Who mattered and who didn't in the past 25 years?)
Piou has worked in related digital fields since 1981 and is important because he has "a vision of where the market might go," Devlin said. "Gemalto positions itself in terms of digital security."
And, despite all the major technological advances of the past 25 years from personal computing to the Internet, Brynjolfsson said you haven't seen anything yet.
"This is the second machine age. I hope that people appreciate the fact that we are just in the early stages," he said. "The first disruption was in the last 25 years. That was just a warm-up stage, a tidal wave that's just getting under way."
Who do you think were the most influential leaders of the past 25 years? Click here to cast your votes.
—By Evelyn Cheng, Special to CNBC. Follow her on Twitter @chengevelyn.