U.S. stock-index futures pointed to a lower open on Wall Street on Friday, with the Nasdaq Composite positioned for weekly losses, with chip manufacturer Nvidia among the technology companies hit after reporting quarterly results.
Nvidia's outlook for current-quarter revenue met expectations, but left investors concerned about reduced demand in the PC industry.
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Apple shares also fell after The Financial Times and others reported the consumer technology company was close to paying $3.2 billion to acquire Beats, a headphone company found by rapper Dr. Dre.
Apple in talks to buy Beats for $3.2 billion
Ralph Lauren fell in early New York trade after the clothing retailer that beat expectations, but warned its operating margin would drop as it spends money to further build its network of stores.
Asian and European shares were pushed lower by developments in eastern Ukraine. Ukrainian pro-Russian rebels announced they would continue with a succession referendum this weekend, despite Russian President Vladimir Putin asking them to call it off. More street clashes are expected on Friday as Ukraine celebrates "Victory Day."
In Asia, Chinese consumer price inflation came in below expectations. Inflation rose an annualized 1.8 percent in April, under estimates for a 2 percent gain and less than March's 2.4 percent rise.
Read MoreIs China catching a whiff of deflation?
Back in the U.S., stocks to watch include Omnicom, after its $35 billion merger with French rival Publicis collapsed. Shares of Publicis traded more than 3 percent lower on Friday morning.
Investors will also wait for any further news of Pfizer's ongoing efforts to purchase U.K. rival AstraZeneca.