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Stock futures retain mild losses after inflation data

U.S. stock-index futures remained lower on Wednesday after the government reported wholesale prices increased the most in more than a year in April.

U.S. producer prices increased 0.6 percent in April, versus a 0.2 percent estimate.

U.S. producer prices up in April.

Deere declined in early New York trading after cutting its full-year revenue outlook; Sears Holdings jumped after the department-store chain said it was exploring options including a possible sale for its stake in Sears Canada.

This follows a strong session on Wall Street on Tuesday, when the S&P 500 crossed 1,900 points for the first time and the Dow reached an intraday record of 16,735.

Applications for mortgages edged a bit higher last week, as rates fell to their lowest level since November, the Mortgage Bankers Association reported.

Read MoreDrop in rates spurs mortgage refinances

Dow-listed Cisco Systems and SeaWorld will post numbers after U.S. markets close.

The Pfizer-AstraZeneca wrangle will remain in focus, with both companies giving evidence again before U.K. lawmakers on Wednesday regarding the potential impact of a merger, this time from a scientific perspective.

Meanwhile, Google has re-released its Google Glass eye wear, which can be bought for $1,500.

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