U.S. stock-index futures remained lower on Wednesday after the government reported wholesale prices increased the most in more than a year in April.
U.S. producer prices increased 0.6 percent in April, versus a 0.2 percent estimate.
Deere declined in early New York trading after cutting its full-year revenue outlook; Sears Holdings jumped after the department-store chain said it was exploring options including a possible sale for its stake in Sears Canada.
Applications for mortgages edged a bit higher last week, as rates fell to their lowest level since November, the Mortgage Bankers Association reported.
Dow-listed Cisco Systems and SeaWorld will post numbers after U.S. markets close.
The Pfizer-AstraZeneca wrangle will remain in focus, with both companies giving evidence again before U.K. lawmakers on Wednesday regarding the potential impact of a merger, this time from a scientific perspective.
Get the best of CNBC in your inbox