"He left for personal reasons," a spokesman for Rosneft said.
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Rosneft also said that Artur Chilingarov, 74, has been proposed to replace Mack on the board. Chilingarov, a member of Russia's upper house of the parliament, is known for his exploration of the Arctic, seen as an important source for Rosneft's future hydrocarbon production.
Mack is currently a senior adviser at KKR & Co and an independent non-executive director at Glencore.
He joined Rosneft's board last June after Rosneft bought Anglo-Russian oil firm TNK-BP for $55 billion from BP and the AAR consortium.
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Six months later Rosneft announced it would buy the majority of the global physical oil trading operations of Morgan Stanley.
Rosneft has said that the deal with Morgan Stanley is intact and will be completed in the second half of this year.