| Cost of Doing Business - 2010 |
| Overall | State | Cost of Business | Workforce | Quality of Life | Economy | Transportation | Technology & Innovation | Education | Business Friendliness | Access to Capital | Cost of Living |
| 6 | Iowa | 1 | 20 | 17 | 10 | 32 | 29 | 16 | 12 | 36 | 17 |
| 32 (tie) | Arkansas | 2 | 11 | 43 | 27 | 36 | 44 | 33 | 39 | 40 | 3 |
| 25 | Oklahoma | 3 | 22 | 41 | 6 | 41 | 36 | 40 | 25 | 32 | 1 |
| 7 | South Dakota | 4 | 15 | 11 | 4 | 27 | 49 | 21 | 3 | 40 | 5 |
| 17 | Missouri | 5 | 29 | 39 | 29 | 7 | 24 | 15 | 25 | 20 | 9 |
| 31 | South Carolina | 6 | 5 | 45 | 46 | 8 | 26 | 43 | 30 | 34 | 24 |
| 8 (tie) | Utah | 7 | 7 | 5 | 23 | 32 | 25 | 48 | 10 | 39 | 17 |
| 26 | Idaho | 8 | 8 | 18 | 39 | 29 | 39 | 47 | 22 | 28 | 11 |
| 21 | Indiana | 9 | 42 | 44 | 41 | 6 | 22 | 16 | 6 | 26 | 13 |
| 16 | Tennessee | 10 | 5 | 49 | 36 | 4 | 23 | 41 | 6 | 35 | 1 |
| 45 | Mississippi | 11 | 21 | 42 | 35 | 45 | 46 | 49 | 47 | 40 | 13 |
| 40 | Kentucky | 12 | 25 | 46 | 44 | 4 | 35 | 37 | 39 | 38 | 3 |
| 14 | Wyoming | 13 | 12 | 10 | 9 | 24 | 50 | 22 | 20 | 27 | 27 |
| 43 | Alabama | 14 | 14 | 48 | 40 | 27 | 30 | 42 | 32 | 40 | 11 |
| 4 | North Carolina | 15 | 3 | 32 | 37 | 10 | 11 | 26 | 13 | 10 | 23 |
| 12 | North Dakota | 15 | 23 | 13 | 3 | 20 | 47 | 18 | 10 | 40 | 17 |
| 46 | West Virginia | 15 | 44 | 40 | 24 | 38 | 48 | 34 | 50 | 40 | 17 |
| 13 | Nebraska | 18 | 18 | 21 | 14 | 18 | 37 | 22 | 8 | 40 | 5 |
| 23 | Oregon | 19 | 33 | 22 | 33 | 15 | 20 | 38 | 28 | 14 | 37 |
| 10 | Georgia | 20 | 3 | 35 | 37 | 2 | 17 | 28 | 17 | 13 | 9 |
| 44 | Louisiana | 21 | 34 | 50 | 25 | 30 | 34 | 32 | 31 | 22 | 24 |
| 11 | Kansas | 22 | 13 | 27 | 7 | 8 | 31 | 11 | 18 | 33 | 5 |
| 18 | Arizona | 23 | 2 | 29 | 41 | 23 | 19 | 45 | 5 | 25 | 34 |
| 29 | Wisconsin | 24 | 46 | 23 | 31 | 14 | 21 | 12 | 27 | 30 | 17 |
| 3 | Colorado | 25 | 10 | 2 | 8 | 36 | 12 | 29 | 4 | 15 | 35 |
| 36 | Montana | 26 | 28 | 15 | 15 | 24 | 44 | 18 | 42 | 36 | 32 |
| 38 | New Mexico | 26 | 27 | 34 | 21 | 18 | 31 | 44 | 45 | 28 | 29 |
| 2 | Virginia | 26 | 9 | 18 | 11 | 12 | 10 | 13 | 2 | 9 | 27 |
| 34 | Ohio | 29 | 48 | 38 | 34 | 2 | 15 | 18 | 38 | 24 | 15 |
| 1 | Texas | 30 | 16 | 29 | 1 | 1 | 4 | 30 | 19 | 7 | 8 |
| 8 (tie) | Minnesota | 31 | 34 | 12 | 5 | 11 | 16 | 9 | 20 | 19 | 15 |
| 41 | Michigan | 32 | 41 | 36 | 47 | 24 | 7 | 35 | 35 | 18 | 24 |
| 15 | Washington | 33 | 30 | 8 | 18 | 35 | 5 | 22 | 34 | 5 | 35 |
| 19 | New Hampshire | 34 | 38 | 4 | 12 | 47 | 27 | 6 | 9 | 16 | 39 |
| 30 | Illinois | 35 | 39 | 24 | 29 | 12 | 14 | 26 | 39 | 6 | 17 |
| 42 | Delaware | 36 | 17 | 47 | 45 | 44 | 33 | 25 | 1 | 20 | 32 |
| 47 | Nevada | 37 | 19 | 37 | 49 | 31 | 37 | 50 | 15 | 40 | 37 |
| 39 | Maine | 38 | 47 | 6 | 25 | 41 | 41 | 7 | 28 | 40 | 39 |
| 5 | Massachusetts | 39 | 23 | 6 | 17 | 39 | 3 | 1 | 14 | 2 | 41 |
| 20 | Pennsylvania | 40 | 42 | 25 | 15 | 16 | 6 | 4 | 32 | 11 | 30 |
| 28 | Florida | 41 | 1 | 31 | 48 | 21 | 13 | 35 | 23 | 17 | 30 |
| 37 | Vermont | 42 | 36 | 3 | 12 | 46 | 40 | 4 | 37 | 40 | 43 |
| 27 | Maryland | 43 | 36 | 28 | 18 | 43 | 8 | 10 | 16 | 12 | 45 |
| 22 | New Jersey | 44 | 32 | 14 | 28 | 32 | 9 | 2 | 35 | 4 | 47 |
| 49 | Rhode Island | 45 | 25 | 33 | 49 | 48 | 28 | 14 | 48 | 23 | 41 |
| 50 | Alaska | 46 | 45 | 26 | 41 | 50 | 41 | 45 | 44 | 40 | 47 |
| 35 | Connecticut | 47 | 40 | 9 | 32 | 40 | 17 | 8 | 23 | 8 | 45 |
| 32 (tie) | California | 48 | 31 | 15 | 18 | 16 | 1 | 31 | 49 | 1 | 49 |
| 48 | Hawaii | 49 | 50 | 1 | 22 | 49 | 43 | 38 | 42 | 31 | 49 |
| 24 | New York | 50 | 49 | 18 | 2 | 22 | 2 | 2 | 45 | 3 | 43 |