| #31 South Carolina |
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| Category | Score | 2010 Rank | 2009 Rank |
| Cost of Doing Business | 321 | 6 | 5 |
| Workforce | 242 | 5 | 6 |
| Quality of Life | 100 | 45 | 48 |
| Economy | 54 | 46 | 47 |
| Transportation & Infrastructure | 142 | 8 | 5 |
| Technology & Innovation | 116 | 26 | 29 |
| Education | 55 | 43 | 39 |
| Business Friendliness | 72 | 30 | 35 |
| Access to Capital | 18 | 34 | 36 |
| Cost of Living | 14 | 24 | 19 |
| OVERALL | 1134 | 31 | 37 |