A Safer Biotech Play?

Shares of Genzyme hit a 52-week high Thursday after it was reported that Sanofi-Aventis could offer up to $20 billion to acquire the Cambridge, Mass.-based company.

Shortly thereafter, Lazard Capital downgraded GENZ shares from 'buy' to 'hold', reports host Melissa Lee. The group said there was limited upside and if there is no take-over, the downside risk could take the share price down to the low $50 range.

"If you're in this ride and you got a 35%, then 42% pop in only four sessions, I think only a fool hangs on for that last mile because it's going to be a rocky ride," says Jon Najarian of optionMONSTER.com.

A biotechnology exchange-traded fund, like SPDR S&P Biotech , the might be a good way to play the possible take-over, says Brian Kelly of Kanundrum Capital. Steve Grasso of Stuart Frankel agreed with Kelly, calling it a safe way to play with possible acqusition without "sticking your neck out."

Karen Finerman of Metropolitan Capital Advisors likes the ETFs, including the XBI and iShares Nasdaq Biotechnology .

• Tomorrow's Trades - Capital Ideas Into Year's End

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TOPPING THE TAPE: CITRIX SYSTEMS

Following better-than-expected revenue, full-year guidance boost and several brokerage upgrades, shares of Citrix Systems rallied more than 20% Thursday.

Brian Kelly of Kanundrum Capital is bullish on the Fort Lauderdale, Fla.-based company because he likes its cloud computing products. In addition to the cloud, Jon Najarian of optionMONSTER.com likes its GoToMeeting, an online space for business meetings and sales demonstrations.

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Trader disclosure: On July 29, 2010, the following stocks and commodities mentioned or intended to be mentioned on CNBC’s Fast Money were owned by the Fast Money traders; Kelly owns (BP) puts; Jon Najarian owns (GLD) puts; Jon Najarian owns (AAPL) call spreads; Jon Najarian owns (MSFT) and short calls; Jon Najarian owns (COP) and short calls; Jon Najarian owns (RRC) and short calls; Jon Najarian owns (MSFT) and short calls; Jon Najarian owns (SYMC) and short calls; Jon Najarian owns (RIMM) and short calls; Jon Najarian owns (IACI) and short calls; Jon Najarian owns (LVS) and short calls; Jon Najarian owns (MGM) and short calls; Jon Najarian owns (XOM) and short calls; Jon Najarian owns (MOS) and short calls; Adami owns (AGU), (BTU), (NUE), (C), (GS), (INTC), (MSFT); Adami’s wife works at Merck; Finerman owns (AAPL); Finerman owns (BAC); Finerman’s firm owns (BAC); Finerman owns (BP); Finerman’s firm owns (BP); Finerman owns (C); Finerman owns (CVS); Finerman’s firm owns (CVS); Finerman owns (FLS); Finerman’s firm owns (FLS); Finerman’s firm owns (GLW); Finerman owns (JPM); Finerman’s firm owns (JPM); Finerman’s firm owns (KFT); Finerman’s firm owns (PLCE); Finerman’s firm owns (RIMM); Finerman’s firm owns (SKS); Grasso owns (ASTM), (ABK), (BAC), (BA), (BGP), (C), (CSCO), (DYN), (JPM), (LPX), (MO), (NDAQ), (PFE), (PRST); Scaramucci owns (APL), (PFE), (MO), (BUD), (KFT), (RAI)

For Steve Grasso:
Stuart Frankel & Co and it’s partners own (BAX)
Stuart Frankel & Co and it’s partners own (COG)
Stuart Frankel & Co and it’s partners own (CUBA)
Stuart Frankel & Co and it’s partners own (DHR)
Stuart Frankel & Co and it’s partners own (DYN)
Stuart Frankel & Co and it’s partners own (ESV)
Stuart Frankel & Co and it’s partners own (GERN)
Stuart Frankel & Co and it’s partners own (HSPO)
Stuart Frankel & Co and it’s partners own (LEN)
Stuart Frankel & Co and it’s partners own (IP)
Stuart Frankel & Co and it’s partners own (MERC)
Stuart Frankel & Co and it’s partners own (NWS.A)
Stuart Frankel & Co and it’s partners own (NYX)
Stuart Frankel & Co and it’s partners own (PDE)
Stuart Frankel & Co and it’s partners own (PFE)
Stuart Frankel & Co and it’s partners own (PRST)
Stuart Frankel & Co and it’s partners own (RDC)
Stuart Frankel & Co and it’s partners own (SYMC)
Stuart Frankel & Co and it’s partners own (TBT)
Stuart Frankel & Co and it’s partners own (TLM)
Stuart Frankel & Co and it’s partners own (TRV)
Stuart Frankel & Co and it’s partners own (XRX)
Stuart Frankel & Co and it’s partners own (SDS)
Stuart Frankel & Co and it’s partners are short (QQQQ)
Stuart Frankel & Co and it’s partners are short (KEG)

For Anthony Scaramucci
SkyBridge Capital owns (APL)
SkyBridge Capital owns (PFE)
SkyBridge Capital owns (MO)
SkyBridge Capital owns (BUD)
SkyBridge Capital owns (KFT)
SkyBridge Capital owns (RAI)

For Brian Kelly
Accounts managed by Kanundrum Capital own (BAK)
Accounts managed by Kanundrum Capital own (VIV)
Accounts managed by Kanundrum Capital own (ORI)
Accounts managed by Kanundrum Capital own (TLT)
Accounts managed by Kanundrum Capital own Swiss Francs
Accounts managed by Kanundrum Capital are short (GLD)
Accounts managed by Kanundrum Capital are short (XME)
Accounts managed by Kanundrum Capital are short (SLX)
Accounts managed by Kanundrum Capital are short (RKH)
Accounts managed by Kanundrum Capital are short (XLK)

For Peter Boockvar
Boockvar owns Euros

For Brian Stutland
Stutland's firm makes a market in VIX Futures

For Gene Munster
Piper Jaffray makes a market in (AAPL), (AMZN), (GOOG), (IACI), (YHOO)

For Joseph LaVorgna
***No Disclosures***