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2. Indianapolis, Indiana

Rental vacancy rate: 13.5%
Homeowner vacancy rate: 5.2%

The capital of Indiana is also one of the emptiest major cities in the country, according to data from the Census Bureau. The 5.2 percent home vacancy rate in Indianapolis ranks it fifth in the country, while the 13.5 percent rental vacancy rate places it 10th. With these levels, the city is more vacant than nearly every other major U.S. metro area.

Photo: Gary Cralle | The Image Bank | Getty Images