The Fed chairman's comments pushed the U.S. greenback higheragainst a basket of major currencies, while gold and silver tumbled sharply.
Stocks gained at the open after news GDP grew at a 3 percent annual rate, logging the fastest gain since the second quarter of 2010, according to the Commerce Department. The economy expanded at a 1.8 percent pace in the third quarter.
And the index of Midwest business activity gained in February to 64.0, hitting its highest level since last April, according to the Chicago ISM.
The strong economic data from this morning is “another reason why you’d expect Bernanke to take the foot off the [QE3] pedal,” said Themis Trading's Saluzzi.
Meanwhile, traders seemed to shrug off the Fed's latest Beige Book report that said the economy expanded moderatelyin January through mid-February as hiring picked up across several districts.
European shares gained as the ECB’s mass loanissuance released extra liquidity into the financial sector. Banks absorbed almost 530 euros of the ECB's second offering of low-cost three-year loans, topping expectations.
Apple's market cap topped the $500 billion levelafter the market closed Tuesday, amid reports that iPad 3 launch may be imminent. Apple is the sixth company to join the so-called $500 billion club. Meanwhile, Stern Agee raised its price target on the tech giant to $620 from $550.
Meanwhile, Hewlett-Packard slipped after the IT company announced plans to cut 275 jobs from its webOS software unit.
NewsCorp ended flat after James Murdoch resigned as Executive Chairman of News International, in the wake of a phone hacking scandal at the news agency.
Meanwhile, Goldman Sachs and Wells Fargo may face federal enforcement actionrelated to mortgage-backed securities deals leading into the financial crisis, according to regulatory filings by the banks.
Among earnings, Costco edged higher after the warehouse club operator topped earnings that topped expectations, thanks to its its lower-priced gasoline that drew more customers to stores.
First Solar plunged to lead the S&P 500 laggards after the firm posted a loss and cut its forecast for 2012 sales.
Toll Brothers rallied after the luxury homebuilder's CEO Douglas Yearly said he sees "improvement everywhere," adding that his company feels "the best" they have in five years. Rivals Pulte Homes , DR Horton and Lennar also jumped.
Weekly mortgage applications rose last weekas interest rates dipped, although demand for refinancing declined, according to the Mortgage Bankers Association.
—Follow JeeYeon Park on Twitter: @JeeYeonParkCNBC—
Coming Up This Week:
THURSDAY; Fed's Pianalto speaks, jobless claims, personal income and spending, ISM mfg index, construction spending, Fed's Lockhart speaks, Fed's Williams speaks, auto sales, chain store sales, EU summit; Earnings from Big Lots, Kroger, Wendy's
FRIDAY: Fed's Bullard speaks, Yelp set to trade
More From CNBC.com: