U.S.stock index futures were lower Wednesday as central banks seemed to drift away from the idea of injecting more monetary stimulus and European shares fell.
Citigroup was set to give back some of the gains it saw a day after an upgrade from analyst Meredith Whitney.
Berkshire Hathaway also slipped after Warren Buffett announced after the market close on Tuesday that he had been diagnosed with stage one prostate cancer. Buffett told CNBC nothing had changed in the company's succession plans.
In Europe, minutes out of the Bank of England showed that only one Monetary Policy Committee member still supported quantitative easing, with ultra-dove Adam Posen giving up his long-standing call for more stimulus.
ECB policymaker Jens Weidmann told Reuters that Spain should take care of its own debt woes and ruled out a third long-term financing operation (LTRO)—or injection of liquidity—from the ECB.
In what looked like more bad news out of Europe, Portugal's prime minister wrote in an editorial in the Financial Times that the country may not return to capital markets in 2013 as previously expected.