U.S stock index futures held losses Tuesday, after major indexes snapped a four-day win streak, amid uncertainties over Spain.
European shares traded lower amid concerns that Spain will not seek assistance from the ECB's bond-buying program.
"Unless we get this (Spanish) uncertainty out of the way, we expect the euro to face some resistance around its highs," Adam Myers, senior currency strategist at Credit Agricole, told Reuters.
Stocks pulled back from multi-year highs Monday, snapping a four-day rally, as euphoria over the Fed's decision to launch another round of QE diminished. But there were deep disagreements between policymakers over whether the new round of bond-buying would actually boost the ailing economy.
Chicago Fed President Charles Evans said the central bank's decision to launch another round of bond buying will provide "important added stimulus" to the economy. Meanwhile, Dallas Fed President Richard Fisher told CNBC he would have voted against itbecause he believes the program won't do much to create jobs.
FedEx reported quarterly earnings that beat analysts' expectations, but shares fell after the package delivery company cut its profit estimatesfor its fiscal year 2013. Rival UPS also slipped.