Meanwhile, voters in Virginia ultimately chose Democrat Tim Kaine over Republican George Allen, who held the seat before being ousted in 2006. The two former governors sparred in the election cycle's most prized political trophies.
In Massachusetts, Democrat Elizabeth Warren — a close Obama ally — was projected the winner against incumbent Republican Scott Brown. Two years ago, Brown shocked the political establishment by narrowly winning the seat once held by Ted Kennedy, scion of America's reigning political dynasties and the so-called "liberal lion of the Senate." A ballot issue legalizing the use of medical marijuana also passed muster with the voters.
In Connecticut, a deep blue state Democrats were seen winning handily, U.S. Rep. Chris Murphy was the projected the winner over Linda McMahon, the wealthy pro-wrestling executive, in a Senate seat being vacated by Independent Joe Lieberman. McMahon first rose to prominence two years ago when she spent millions to claim a seat from Democrat Chris Dodd. Ultimately, Democrat Richard Blumenthal won the election.
Independent candidate Bernie Sanders was the projected winner in Vermont, a state where President Barack Obama was projected as winner. Republican challenger Mitt Romney was projected as the winner of Indiana's 11 electoral college votes.
In Maine, independent Angus King was projected the winner of a seat being vacated by Republican Senator Olympia Snowe. The former governor defeated Republican Charlie Summers and Democrat Cynthia Dill.
Michigan Democrat Debbie Stabenow was projected to have prevailed over her challenger, former Republican Pete Hoekstra. The state's 16 electoral college votes were awarded to Barack Obama, NBC News projected.
Nebraska was seen as a pick-up for the GOP, with Republican Deb Fischer prevailing over former Democratic senator and governor Bob Kerrey, who until recently was president of the New School University in New York City.
In Minnesota — a hive of battleground activity at the presidential level — incumbent Democrat Amy Klobuchar was seen the winner of a contest that pitted her against Republican Kurt Bills. Elsewhere, New York Senator Kirsten Gillibrand was the projected winner over Republican Wendy Long, holding the seat once held by Secretary of State Hillary Rodham Clinton and Daniel Patrick Moynihan.
The reign of Texas Republican Senator Kay Bailey Hutchison was poised to end with the election of fellow GOPer Ted Cruz, who was the projected winner in a contest against Democrat Paul Sadler.