Japan's benchmark Nikkei average closed down 0.40 percent at 10,494.71 on Friday, while the broader Topix shed 0.47 percent to 909.39.
Most Asian stock markets gained ground in thin pre-holiday trade on Thursday, led by Japan and China.
China's key stock index ended up, with telecommunications-related shares firmer on strong subscriber growth, but some recently listed companies slipped below their IPO prices with sentiment weighed down by worries over rising share supplies.
Asian stocks on Tuesday got a lift from the stronger close on Wall Street, with Seoul, Tokyo and Australian markets all closing higher, but China bucked the regional trend.
Asian stock markets were trading mixed on Monday, with technology shares getting a boost from Nasdaq's strong finish on Friday.
Asian stock markets stumbled at the open on Friday, following the sell-off on Wall Street which saw the Dow Jones Industrial index fall more than 1 percent.
Asian stock markets were mostly lower on Thursday afternoon, led by Shanghai's 2 percent slide.
Most Asian markets were in the red on Wednesday after U.S. stocks snapped their winning streak on fears of an interest rate hike and a sluggish outlook from General Electric
Asian stocks ended mixed on Tuesday as investors stayed cautious ahead of the two-day Federal Reserve meeting despite a positive end on Wall Street in the overnight session.
Asian stocks rebounded on Monday after Dubai said it had received $10 billion from Abu Dhabi to repay debt, which pushed down the yen but boosted the euro and emerging Asian currencies as risk appetite improved.
Asian stocks rose on Friday after a slew of Chinese data showed the world's third-largest economy is on a brisk recovery path, fueling optimism that the global recovery is on track.
Asian stock markets ended mixed on Thursday, despite the modest gains on Wall Street overnight.
Asian stock markets traded lower on Wednesday, following the negative lead on Wall Street overnight.
Asian stock markets ended lower on Tuesday, after comments from Federal Reserve Chief Ben Bernanke renewed concerns over a sluggish U.S. economy.
Asian stock markets painted a mixed picture on Monday, following a positive finish on Wall Street in the previous session. Tokyo rose 1.45 percent to a six-week closing high and Taipei ended Monday's session up 1.63 percent, a three-week peak. But Sydney fell as resource-related stocks dropped on the back of a slump in gold and copper prices.
Asian stock markets ended mixed Friday, as Sydney fell 1.5 percent while Shanghai gained 1.6 percent.
Most Asian stock markets gained ground on Thursday, led by Tokyo's 3.8 percent but Shanghai closed lower.
Asian stock markets tracked a strong session on Wall Street, which saw the Dow climbing more than one percent to end at its highest level so far this year. Key indices in Seoul and Hong Kong chalked up over 1 percent each.
Asian stocks gained ground and Tokyo reversed course on Tuesday afternoon, as worries eased over Dubai's debt problems. The Nikkei 225 closed 2.4 percent higher, driven by news of a surprise BOJ meeting, which weighed on the yen and lifted exporters.
Asian stock markets staged a comeback Monday after Friday's steep losses, as worries about the potential negative impact of a Dubai debt default began to fade.