The safe-haven yen hit a 3-1/2 year high against sterling on fears about the impact of Brexit.
U.S. stock index futures indicated a mostly lower open Thursday amid U.S. data and higher oil prices.
U.S. stocks closed lower Tuesday, amid record lows in the benchmark 10-year Treasury yield, as global growth concerns weighed.
U.S. sovereign bond prices were higher Tuesday, after being closed Monday for the July 4 holiday, resuming a strong "safe-haven" bid.
Europe slipped sharply lower on Tuesday, as a fall in oil prices and concerns over global growth weighed on sentiment.
Most Asia markets stumbled on Tuesday, with shares in Australia falling amid an uncertain election outcome and an on-hold central bank.
Gold was near $1,350 an ounce on Tuesday after the previous day's rally ran out of steam.
U.S. stock-index futures pointed to a lower open Wednesday as benchmark Treasury yields held near record lows and overseas stocks fell.
Oil prices tumbled as investors worried Britain's exit from the European Union would slow the global economy.
The Japanese yen rose almost 1 percent against the euro and dollar while sterling fell to new long-term lows.
European markets ended lower on Monday, as concerns about the U.K.'s Brexit vote returned to weigh on investor sentiment.
Australian shares rose, shrugging off uncertainty over its inconclusive election outcome, to join a continuing post-Brexit rally across Asia markets.
Oil prices rose following comments from the Saudi energy minister, but signs of slowing demand in Asia weighed.
Gold rose as political turmoil following Brexit supported prices after activity in China pushed them back towards last week's high.
The Aussie recovered from a wobbly start as commodities rose on expectations that central banks are likely to provide more stimulus.
U.S. stocks closed slightly higher Friday, the first day of the quarter, in a fourth day of gains after the post-Brexit sell-off.
U.S. government debt prices were higher, building on a global bonds rally, as investors looked to the release of a host of data.
European stocks finished the session with solid gains on Friday as the recovery in global markets continued, despite uncertainties over the Brexit vote.
Asia markets ended mostly higher on Friday, tracking global stocks' recovery from the post-Brexit sell-off despite a slew of downbeat data.
U.S. stock index futures indicated a lower open Tuesday with "risk-on" sentiment pausing for breath after a strong rally last week.