Asian indexes traded lower early on Wednesday after a softer lead from Wall Street, with the vote on a health-care bill in the U.S. delayed.
Stocks fell as large-cap technology declined more than 1 percent, while a Senate vote delay raised heighten policy uncertainty.
European markets closed lower on Tuesday after the president of the European Central Bank, Mario Draghi, defended the bank's loose monetary policy and said a premature ending to easing could lead to another recession.
Markets in Asia closed mixed on Monday as traders watched for speeches from central bankers and as oil prices rose.
The euro hit its highest level in over a week on Tuesday as the dollar slipped.
Gold rose Tuesday after hitting a six-week low on Monday.
Oil prices rose on Tuesday as investors covered short positions, but worries over a persistent global supply glut still lingered.
U.S. government debt prices were lower as European Central Bank President Mario Draghi raised the possibility of monetary policy changes.
Nasdaq futures pulled back after Google was hit with a record fine of $2.7 billion by European Union regulators.
U.S. equities closed mixed on Monday as a rise in the financials sector helped offset losses from large-cap technology stocks.
European bourses closed higher on Monday as banks rallied on the news that Italy had reached a deal to wind up two ailing regional banks.
Markets in Asia closed in the green on Monday as oil prices rose, despite news Takata had decided to file for bankruptcy.
Financial investors' lack of faith in another U.S. interest rate rise this year kept the dollar pinned back.
Oil prices rebounded on Monday, but were hemmed in by a relentless rise in U.S. supply and a surge in demand for short sale contracts.
Huge sell order and strong dollar push gold to six-week low
U.S. government debt prices traded mostly higher, as investors digested economic data and the first of three major note sales.
U.S. stock index futures pointed to a higher open, as investors watched an uptick in oil prices carefully.
U.S. equities closed mostly higher on Friday as energy stocks stemmed this week's sell-off.
European stocks closed lower on Friday as investors monitored oil prices and business activity in Germany dipped to a four-year low.
Asian markets traded sideways on Friday after the sell-off in mainland China on Thursday and as oil prices advanced off lows.