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14. Mrs. Doubtfire (1993)

Return on investment: 1160%
Budget $38 million (inflation-adjusted)
Gross revenue $441 million

Cross-dressing has been the subject of successful movies for years. But while Some Like it Hot won all the critical accolades and Tootsie boasted the quality writing and serious method actors, the Robin Williams vehicle Mrs. Doubtfire was the most commercially successful of all.

Since its 1993 release, the movie earned over $441 million dollars, almost twelve times its cost. Not bad for a movie whose biggest laughs come from funny voices and from a pair of prosthetic breasts catching fire.

Photo: Twentieth Century Fox