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13. There’s Something About Mary (1998)

Return on investment: 1194%
Budget $31 million (inflation-adjusted)
Gross revenue $370 million

There’s Something About Mary really put the “gross” in gross revenue. The 1998 Farrelly Brothers comedy about love lost and love regained had something to offend everyone, from jokes about bodily fluids to laughs at the expense of the mentally retarded.

The movie was so raunchy that it stood a good chance of alienating audiences with its relentlessly lowbrow humor. However it was genuinely funny, and good word of mouth buoyed the movie to earnings of almost $370 million, almost twelve times its budget.

Photo: Twentieth Century Fox