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1. My Big Fat Greek Wedding (2002)

Return on investment: 6150%
Budget $6 million (inflation-adjusted)
Gross revenue $369 million

My Big Fat Greek Wedding was a 2002 romantic comedy that women loved and their boyfriends suffered through. The story of a Greek-American woman’s relationship with a non-Greek man and the clash of civilizations that ensues was made on a very small budget and opened in limited release. But its performance grew slowly and steadily, and the movie developed over time into a popular crowd-pleaser that far exceeded expectations.

Despite its status as a small independent film, and despite never holding the number one spot at the box office, the movie went on to earn almost $369 million, a staggering, unbelievable return of over sixty-one times on its investment. For that reason, My Big Fat Greek Wedding is the most profitable film of all time.

Photo: IFC Films