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For most Americans, Alka-Seltzer is the go-to antacid and pain reliever when that extra slice of pizza doesn’t agree with you.

Part of its popularity comes from its U.S. television advertisements, which had tunes (“plop plop, fizz fizz”) and catchphrases (“I can’t believe I ate the whole thing”) so memorable that decades later people still mention them in conversation.

Alka-Seltzer is owned by Bayer AG, a German pharmaceutical company. It operates multiple sites all over the U.S. for administration, marketing, research and development and manufacturing.