The FTSE Small Cap index closes 0.2 percent lower, while the bluechips shed 0.6 percent, and the mid caps lose 0.7 percent.
Oxford BioMedica falls 6.9 percent as the firm says it is closing amid-stage clinical trial of its cancer vaccine TroVax in U.S. patients withprostate cancer, dealing a further blow to the troubled product.
Thorntons gains 1.6 percent as the chocolate group says trading isin line with management expectations, with first-quarter total sales down 1percent to 46.0 million pounds primarily due to planned store closures, althoughit is cautious on the outlook for its upcoming Christmas peak trading season.
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