The president scolded opponents of the Affordable Care Act for insisting that the law be delayed or rolled back. He said that it will eventually provide affordable insurance to millions of people who have lived in fear of huge medical bills.
He said that the insurance marketplaces where people can shop for new coverage will open for business on Tuesday regardless of what Congress does. And he bluntly told critics of the law that they will not win in their crusade to undo his signature achievement.
(Read more: A tax on medical devices stirred the budget)
"An important part of the Affordable Care Act takes effect tomorrow," Mr. Obama said. "That funding is already in place. You can't shut it down."
In remarks that took about ten minutes, Mr. Obama sought to describe the painful impact of a government shutdown, not only on federal employees but also on people who depend on services that the government would stop providing.
(Read more: Senate rejects House bill, shutdown looms)
He said that Social Security recipients will continue to receive their checks and that Medicare patients will still be able to be seen by their doctors. Mail delivery will continue and essential personnel in the military, air traffic control booths, prisons and border patrols will stay on the job.
But he said that NASA will shut down "almost entirely" except for mission control operations dedicated to the astronauts on the International Space Station. He said federal office buildings will close, parks and monuments will be shut down, and veterans will find their support services unstaffed.
(Read more: Here comes the DC shutdown: What you need to know)
"Hundreds of thousand of these dedicated public servants who stay on the job will do so without pay," Mr. Obama said. "These Americans are our neighbors. Their kids go to our schools. They are the customers of every business in this country. They would be hurt greatly."
—By Michael D. Shear, The New York Times.