NQ Mobile continued its fall after a negative report by short seller Muddy Waters. Macquarie maintained an "outperform" rating on the stock with a price target of $26 saying it expected the company to report strong earnings on Nov 13.
Facebook fell below $50 a share ahead of its earnings on Wednesday. The WSJ said the company was unable to land a deal to buy photo-sharing social media company Snapchat for $1 billion.
Teva lost ground after the company denied reports its CEO was considering resigning due to a rift with its board of directors.
Homebuilders were lower following a 5.6-percent drop in pending home sales in September. Lennar, KB Homes, Pulte and Toll Brothers were all trading to the downside.
Edwards Lifesciences moved lower despite reporting better-than-expected third-quarter results as investors focused on the company's weak guidance.
Biogen Idec gained ground after the company posted better-than-expected third-quarter earnings, boosted by sales of its multiple sclerosis drug Tecfidera.
General Electric rose after Credit Suisse raised its price target on the conglomerate to $29 from $27.
Loews fell after the company reported lower adjusted net income for the third quarter, pressured by falling profits from its Diamond Offshore drilling unit.
—By CNBC's Rich Fisherman.
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